Adelaide will face Greater Western Sydney as selected at Adelaide Oval on Tuesday evening.
Chayce Jones, Brad Crouch, Darcy Fogarty and Andrew McPherson will start the game on the interchange.
Coach Matthew Nicks made just one change to the side that defeated Hawthorn in Round 15, recalling young defender McPherson in exchange for Myles Poholke.
First bounce is at 5.10pm and will be televised live on 7mate in Adelaide along with nationwide on Fox Footy.