Adelaide will face the Saints as selected at Adelaide Oval on Monday night.
Brad Crouch, David Mackay, Fischer McAsey and Andrew McPherson will start the game on the interchange.
Coach Matthew Nicks made two changes to the side that lost to West Coast in Round Six, recalling forward Taylor Walker and wingman Paul Seedsman.
Captain Rory Sloane will miss the next four-to-six weeks due to a broken hand while Billy Frampton was omitted.
First bounce is at 7.10pm (ACST) and will be broadcast live on Fox Footy and Seven Mate in Adelaide.