Adelaide has beaten St Kilda 26 times from 42 attempts since the Crows joined the competition in 1991.
The Saints are one of only two teams (the other being Collingwood) the Crows have recorded a draw against - Round Four, 1994 when both sides finished on 79 points.
Adelaide has not lost to St Kilda since Round 18, 2011 when the Crows suffered a 103-point defeat at Marvel Stadium.
Aside from that loss, the Crows have won 10 of the last 11 games, most recently a 49-point win at Marvel Stadium in Round Three, 2018.
Across the past five games, Sam Jacobs and Rory Laird led the way for Adelaide.
Laird is averaging 32 disposals, 6.3 marks and 3.7 tackles while Jacobs sits on 33.7 hitouts and 2.7 tackles.
Jack Steven has been the standout player for the Saints with 30.7 touches.
Don Pyke possesses the more favourable coaching record, having won 63.82 per cent of his 76 games in charge of the Crows.
St Kilda coach Alan Richardson has won 36.21 per cent of his games since joining the Saints in 2014 from Port Adelaide.
Adelaide sits 12th on the AFL ladder having won two games from the opening five rounds, while the Saints have enjoyed a strong start to 2019 and sit second with four wins and one loss.