Adelaide will face the Swans at Adelaide Oval as selected.
Chayce Jones, Lachlan Murphy, Matt Crouch and Bryce Gibbs will start the game on the interchange.
Young defender Fischer McAsey will make his AFL debut while Port Adelaide recruit Billy Frampton will play his first game for the Club.
First bounce is at 4.35pm ACDT and will be broadcast live on Channel 7, Fox Footy and Kayo.
The game will be played behind closed doors.