Crows leaders Taylor Walker and Daniel Talia will miss Sunday’s clash with West Coast at Domain Stadium.
Walker (toe) and Talia (ankle) failed to overcome minor injury complaints at training and won’t make the trip to Perth.
Both are expected to play in Adelaide’s opening final next month.
Ruckman Reilly O’Brien and forward Jonathon Beech replace the pair in Adelaide’s 25-man squad.
Crows General Manager of High Performance Matt Hass said the Club opted for a no-risk approach with the duo.
“Both Taylor and Daniel were close to playing, but didn’t quite come up in time,” Hass said.
“Taylor’s toe flared up a bit on the track this week and Daniel’s movement has been restricted somewhat by that ankle.
“We weren’t comfortable risking them for this week, but we’re confident they’ll be fine for our first final.”
The Club’s final 22 will be named on afc.com.au at 4.30pm (ACST) on Friday afternoon.