Brisbane vice-captain Tom Rockliff has been ruled out of Saturday night's match against Adelaide with a dislocated shoulder.
But in better news for the club, captain Dayne Beams could make a return against the Crows at the Gabba.
Rockliff suffered his injury in the dying minutes of Saturday's loss to Hawthorn and is unlikely to return until after the Lions' bye in Round 11.
"It's going to keep Tom out for two or three weeks," Lions head of medical Peter Blanch told the club's website.
Beams is a chance to return after two weeks on the sidelines with a quad injury.
Blanch said the skipper had been training strongly.
"He'll be touch and go this week, we'll probably make a decision on that at the end of training on Thursday."
The Lions are already missing experienced midfielders Mitch Robinson (broken foot) and Allen Christensen (collarbone).
Running defender Tom Cutler (hamstring) is available for selection.
Despite losing seven matches straight, Lions midfielder Dayne Zorko said the Lions were upbeat about their chances against Adelaide.
"We're a young, vibrant group," he said.
"We're coming to work to a job we absolutely love.
"Adelaide is a very classy outfit. They're right up there to win the premiership, they're a team to beat."
Zorko said there was more to slowing the Crows down than limiting influential midfielder Rory Sloane, who has been held to just 18 and 11 disposals respectively in Adelaide's past two losses.
"It might help in some areas, but they've got so many ball-winners and so much run everywhere, all over the park, I find it hard to believe that if you stop Sloane you stop Adelaide, because they're so powerful everywhere," he said.