Adelaide has faced the Lions 32 times since the Brisbane-Fitzroy merger in 1996.
The Crows hold a slender 17-15 lead over the Queensland side and have won the past seven encounters.
Brisbane has not defeated Adelaide since Round 21, 2012 at the Gabba.
Over the past nine seasons, the match-up has been played in Adelaide just twice (Round 21, 2015 and Round 20, 2016).
Crows co-captain Taylor Walker enjoys playing against the Lions and averaged 4.7 goals in his last three games.
Tom Lynch has played four out of the last five games between the sides, averaging 1.8 goals and 25 touches.
From the Lions, veteran ruckman Stefan Martin has been the standout player with 19.7 disposals, eight tackles and 33 hitouts per game.
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Adelaide’s second all-time largest victory was against Brisbane in Round 20, 2016 when the Crows 27.15 (177) defeated Brisbane 6.3 (39) at Adelaide Oval
Brisbane’s all-time largest victory came against the Crows in Round 17, 2004 when the Lions 29.15 (189) defeated Adelaide 6.12 (48) at the Gabba.
The Lions are enjoying their best start to the season since 2009, when they also had five wins from the opening eight games.
Adelaide did not play any matches in the Saturday lunch time slot last year - Brisbane played seven and won two.
The match will be the third time Don Pyke and Brisbane coach Chris Fagan face off.